It is also used to treat rheumatoid arthritis, and there are a total of approximately 2.1 million patient-years of exposure in patients with this condition, suggesting an excellent safety and tolerability profile.

Teriflunomide is a once-daily, orally available immunomodulator that reversibly inhibits the mitochondrial enzyme dihydroorotate dehydrogenase, which plays an important role in pyrimidine synthesis needed for DNA replication. By hindering T- and B-cell proliferation and function in response to autoantigens, the drug functions as a disease-modifying therapy for MS. However, it does not affect the replication and function of hematopoietic cells, memory T cells, or other cells living on their pyrimidine pool through the salvage pathway.

The boxed warning points out that, based on animal studies, the drug may be teratogenic, important because many patients with MS are women of childbearing age.

Cause: Uncontrolled Diabetes is the main cause for Diabetic Retinopathy. High blood sugar causes damage to retinal blood vessels which increases the pressure in blood capillaries and made them weak.

Diabetic retinopathy affects both eyes and initially shows no symptoms. In progressive stages, symptoms like swollen blood, fluid leak, abnormal new blood vessels on retina surface occurs and all these results into irreversible Vision loss.

Omega 3 & Diabetic Retinopathy: Omega-3 fatty acid is highly concentrated in retina and significantly preserved retinal function. Lack of omega 3 supplement in daily diet may cause various eye problems. Omega 3 fatty acid plays vital role against development and progression of diabetic retinopathy. In diabetic retinopathy patients, Omega 3 supplement protects against the growth of abnormal blood vessels and promotes the growth of healthy blood vessels. It reduces the inflammatory eye conditions.

Supportive studies: Studies shows that possible protective mechanism is because of an enzyme 5-lipoxygenase (5-LOX) that converted omega 3 fatty acid into an acid called 4-HDHA which slows the growth of abnormal blood vessel. Regular intake of Omega 3 slows down the progression of retinopathy severity and vision loss by approx. 40-50 %.

Studies also suggest that intake of omega-3 fatty acid by pregnant women may significantly decrease the occurrence of retinopathy of prematurity (ROP) in premature infants. It significantly supports the development of eye in fetuses.

Omega 3 fatty acid plays a vital role to maintain eye health and reduces the occurrence of diseases. 

In the current study, children with URIs and nocturnal cough were given either 1 of 3 different honey products or a placebo 30 minutes before bedtime, based on a double-blind randomization plan. The primary outcome evaluated was a subjective change in cough frequency, based on parent surveys. Secondary outcomes measured included a change in cough severity, the effect of the cough on sleep for both the child and the parent, and the combined score on the pre- and postintervention surveys.

Herman Avner Cohen, MD, from the Pediatric Ambulatory Community Clinic, Petach Tikva, Israel, and colleagues compared symptom scores for each treatment group before and after the intervention and found that patients in all 3 honey groups demonstrated significant improvement compared with patients treated with placebo. There were no significant differences among the different types of honey.

“The results of this study demonstrate that each of the 3 types of honey (eucalyptus, citrus, and labiatae) was more effective than the placebo for the treatment of all of the outcomes related to nocturnal cough, child sleep, and parental sleep,” the authors write.

The researchers enrolled 300 children with URIs, aged 1 to 5 years, who were seen at 1 of 6 general pediatric community clinics between January 2009 and December 2009. Patients were eligible if they had a nocturnal cough attributed to the URI. Children were excluded if they had symptoms of asthma, pneumonia, laryngotracheobronchitis, sinusitis, and/or allergic rhinitis. Patients who used any cough or cold medication or honey in the previous 24 hours were also excluded.

Parents were asked to evaluate the children the day of presentation, when no medication had been given, and then again the day after a single dose of 10 g of eucalyptus honey, citrus honey, labiatae honey, or placebo (silan date extract) had been administered before bedtime. Pre- and postintervention subjective assessments were obtained using a 5-item Likert-scale questionnaire regarding the child’s cough and sleep difficulty. Only those children whose parents rated severity as at least a 3 (on a 7-point scale) for at least 2 of the 3 questions related to nocturnal cough and sleep quality on the preintervention questionnaire were included.

Of the 300 patients enrolled, 270 (89.7%) completed the single-night study. The median age of these children was 29 months (range, 12 – 71 months). There was no significant age difference among the treatment groups. Symptom severity was also similar among all 4 treatment groups.

Adverse events were reported for 5 patients and included stomachache, nausea, and vomiting and were not significantly different between the groups.

The drug was given priority review by the FDA for this indication, a statement from Pfizer notes, and brings to 5 the number of approved indications for pregabalin in the United States; others include diabetic neuropathy, postherpetic neuralgia, fibromyalgia, and partial-onset seizures in adults with epilepsy who take 1 or more drugs for seizures.

More than 100,000 patients, or about 40% of patients with traumatic or nontraumatic spinal cord injury in the United States, develop neuropathic pain associated with the injury. “Neuropathic pain associated with spinal cord injury can be severely debilitating and may significantly hinder rehabilitation and the ability to regain function,” the statement said.

Neuropathic pain can be experienced above, at, or below the level of injury and is typically not confined to one area of the body, the statement notes. “Approximately one-third of spinal cord injury patients report below-level neuropathic pain that is severe or excruciating,” they write. It can be begin as soon as 2 weeks after the injury and persist up to 25 years.

The approval is based on results of 2 randomized, double-blind phase 3 trials comparing flexibly dosed pregabalin (150 to 600 mg/d) with placebo in 357 patients. Patients were allowed to continue other medications, including other pain medications, such as nonsteroidal anti-inflammatory drugs, opioids, and nonopioid medications. One study included only patients with traumatic spinal cord injury, and the other included about 5% of patients with nontraumatic injuries.

Studies showed pregabalin significantly reduced neuropathic pain between baseline and 12 and 16 weeks in each study, respectively, vs placebo. More patients taking pregabalin showed 30% and 50% reductions in pain than those taking placebo. For some patients, the reduction in pain was significant as soon as week 1 and continued throughout the trial, the statement notes.

The most common adverse events with pregabalin were somnolence, dizziness, dry mouth, fatigue, and peripheral edema. Antiepileptic drugs, including pregabalin, increased the risk for suicidal thoughts or behaviors. There have been postmarketing reports of angioedema and hypersensitivity with pregabalin, the release adds. Other reactions include blurred vision, weight gain, constipation, euphoric mood, balance disorder, increased appetite, and abnormal thinking (primarily difficulty with concentration and attention).

“This milestone represents an important opportunity for physicians to more effectively manage the debilitating neuropathic pain that often accompanies spinal cord injury,” said clinical study investigator Diana Cardenas, MD, MHA, professor and chair, department of rehabilitation medicine, University of Miami Miller School of Medicine and chief of service for rehabilitation medicine and medical director of Jackson Rehabilitation Hospital, Miami, Florida, in the Pfizer statement. “Given the clinical challenges of investigating neuropathic pain in this patient population, any advancements in treatment are welcome by physicians and patients alike.”

Glaucoma is an eye disorder in which internal eye pressure (Intraocular pressure-IOP) is very high. In this condition, eye has too much aqueous humor pressure either because of over production of fluid or of improper draining. This leads to damage of optic nerve results in Vision loss. This nerve acts like an electric cable with over a million wires. It is responsible for carrying images from the eye to the brain.
According to World Health Organization, Glaucoma is the second leading cause of blindness (behind cataracts).

GLAUCOMA SYMPTOMS:
Glaucoma, known as “silent thief of sight” as it causes no pain and shows no symptoms in early stages and quietly causes vision loss. As no symptoms occur, the best way to diagnose this form of glaucoma is by periodic eye examination. Onset of any of symptoms like blurred vision, severe eye pain, red eyes, headache, nausea and vomiting is the warning alarm for eyes.

GLAUCOMA CAUSE:
A clear fluid flows in and out of the space at the front of the eye, nourishing nearby tissues. Glaucoma causes the fluid to pass through too slowly or to stop draining altogether. As the fluid builds up, the pressure inside the eye increases, causing damage to the optic nerve and vision loss.

RISK FACTORS:
Age: Glaucoma is more common among older people. People above 40 are 6 times more likely to get glaucoma.
Family History: The most common type of glaucoma, primary open angle glaucoma, is hereditary. Family history of glaucoma increases the risk of glaucoma four to nine times.
Indiscriminate use of Steroids: Studies indicate Steroids increase intraocular pressure. These could be in the form of Oral medications, Steroid Inhalers and Steroid Eye Drops used for long periods of time.
Injury to Eye: Injury to the eye may cause secondary open angle glaucoma. This type of glaucoma can occur immediately after the injury or years later.

CARE, NUTRITION AND SUPPLEMENTS:
Glaucoma is controlled and treated if detected in early stages. Early detection of Glaucoma save the patient form vision loss and eye damage. Glaucoma is control with Medicines (Oral and eye-drops) and Laser Surgery.

Other than Medicines and Surgery, following care, nutrition and supplements are required to keep eye healthy and free from eye problems:

1. Exercise: Regular physical activity can lower intra ocular pressure by a little bit.

2. Food & Diet: Carrots, Spinach, Green leafy vegetables, citrus fruits, blueberries, cherries, tomatoes, whole milk, egg, lean meat and seafood should be taken to keep eye healthy and full of vision. And should limit the intake of caffeine, alcohol and smoking.

3. Nutritional Supplements: There are few supplements known to improve the clinical condition of Glaucoma.

A. Alpha Lipoic Acid (ALA): Alpha Lipoic Acid (ALA) is very powerful antioxidant and this antioxidant property is helpful in improving eye conditions like glaucoma, cataract and diabetic retinopathy. Clinical studies shows that, regular intake of 150 mg of Alpha Lipoic acid improves visual acuity and colour perception by 45- 47% in glaucoma patients. ALA shows strong neuroprotective properties which significantly prevent ischemic optic nerve damage and improves fluid discharge.

Ref.: Filina AA, et al. Lipoic acid as a means of metabolic therapy of open-angle glaucoma. Vestn Oftalmol 1995; 111:6-8.

B. Omega-3 Fatty Acids: Studies show direct association between Omega 3 fatty acid and eye health. Omega 3 fatty acid is helpful in inflammatory and intraocular pressure (IOP) conditions. It is studied that with the regular consumption of Omega 3 fatty acid leads to decrease in IOP with age by increasing the aqueous outflow in glaucoma patients. Omega 3 fatty acid helps to decrease the eye inflammation by reducing the production of inflammatory cellular signaling molecules.

Ref.: 1. Cellini M, Rossi A & Moretti M. The use of polyunsaturated fatty acids in ocular hypertension. Acta ophtalmol Scand 1999;77 (suppl. 229):54-55
2. Dietary omega 3 fatty acids decrease intraocular pressure with age by increasing aqueous outflow. Invest Ophthalmol Vis Sci. 2007.

However, by taking statins, one or more patients will develop diabetes and 20% or more will experience disabling symptoms, including muscle weakness, fatigue, and memory loss

Ref: JAMA 2012; 307: 1489-4532

Even if it is considered top-of-the-line HGH supplements, it can still contain some negative insights from users. HGH is highest in developing adolescents and the older we get, the much less we generate. Other health improvements include an increased metabolism, weight loss and increased muscular mass, that’s why it can be therefore preferred among athletes and bodybuilders. But using a “releaser” or stimulator product, your. The HGH throughout Sytropin is natural it can be enhanced by six growth factors and eight amino acid releasers to enhance great and bad the compound and how your body reacts the idea.

Some people experienced a rise in regrowth, but no harmful effects. By like the following ingredients their own specific dosage – L-Glutamine 200 mg. All I want, but, to be able to remain younger on the lookout for somewhat added time. So you see that a persons human growth hormone may be very much a significant portion of body of a human and growth system. although it could possibly, if you’re willing to stop paying it.

That way, you might be keeping yourself completely informed and could be certain you’re getting the easiest product an individual. More importantly it can be a superbly legal approach to obtain HGH. Since treatments itself utilizes synthetic compounds which will cause serious unwanted side effects and complications to astonishingly, you might be putting yourself any serious risk if you take HGH injections. Pills and sprays are wonderful choices to injections, and so they offer numerous advantages. The higher regarding human growth hormone can improve heart function, boost metabolism, strengthen the defense mechanisms, reduce body fat, stabilize blood sugar and increase energy.

The Food Safety and Standards Act. 2006 has come into force with effect from 05^th August. 2011. It defines a Food Business Operator (FBO) as a person engaged in the business of food manufacture, processing, packaging, transportation, distribution, storage and import etc. and includes food services, catering services and sale of food or food ingredients.

REGISTRATION AND LICENSING

• All Food Business Operators (FBO) in the country have to be registered or licensed in accordance with the cutoff limits laid down in the Food Safety and Standards (Licensing and Registration of Food Business) Regulations, 2011.
• A milk producer whose production capacity of the Milk & Meat Products is less than 100 Kg/Ltr. per day, or is handling milk less than 500 Ltr. per day, meat or meat products producer in the capacity for slaughter of maximum 2 large animal or 10 small animals or 50 poultry birds per day or any other FBO where annual turnover is less than Rs 12 Lakh is termed as Petty Food Business Operator (PFBO) and is required to be registered.
• Schedule 1 of the Regulations defines the businesses that will be licensed by FSSAI Regional offices. All other businesses will have to obtain license from the local District Designated Officer of the state.
• Application can be filed online at foodlicensing.fssai.gov.in for central licensing.

EXISTING LICENSEES

■                    Convert your existing food licenses / registration into FSSAI license Registration before 5^th August, 2012

■                    No license registration fee will have to be paid for the remaining period of the validity of the earlier license or registration.

■                    All FBO should have valid license at all time.

• If the existing license registration has expired after 5″ August. 2012 apply for its renewal immediately.

■                    No pre – inspection required.

■                    A New FSSAI license number will be issued.

• Comply with existing provisions of Food Safety and Standards (Licensing and Registration of Food Business) Regulations, 2011.

For further details visit fssai.gov.in or Dial-Toll free helpline 1800112100

Issued in Public interest by

Food Safety and Standards Authority of India

FDA Bhawan, Kotla Road,

New Delhi – 110002

CoQ10: Every day, you chew a supplement that contains 60mg of coenzyme Q10, or CoQ10, an antioxidant that helps maintain the soft tissues in your body-including your gums. Some early research suggests that taking CoQ10 can even help shrink the pockets caused by gum disease.

Calcium: Calcium, a mineral found in your jawbone. If you don’t get enough calcium, your jaw weakens, loosening your teeth. Men and women from ages 19 to 49 need 1,000mg of calcium, daily, while those over 50, require 1,200mg. A cup of milk or yogurt packs about 300mg and an ounce of most cheeses has around 200mg.

Vitamin D: To absorb calcium, your body needs vitamin D. According to the WHO recommendation, a full third of Indians don’t get enough. You must follow the recommendation and get at least 400IU daily. Milk has about 100IU per cup and a 3-ounce serving of fattier fish, like salmon or mackerel, contains about 300IU. If you don’t drink milk or eat fish, you could probably use a supplement of 400 IU daily.

Vitamin C: There’s one more super-important nutrient for your teeth: Vitamin C. It’s a building block for collagen, which helps keep your teeth attached to your gums. A study in the Journal of Periodontology found that men and women who consumed less than 60mg of vitamin C daily were 150 percent more likely to have gum disease than people who took in at least 180mg. Fruit and veggies are the major sources of vitamin C (One orange alone has 60mg). You get enough C in your diet, but if you don’t, consider taking a supplement.

Omega-3 fatty acids: Studies shows that “People with low intake (of DHA) had an approximately 1.5 times higher incidence rate ratio of periodontal disease progression”. Regular intake of Omega-3 supplements is helpful in the treatment of periodontal disease and other gum diseases. Its anti-inflammatory effects effectively reduce the chances of gum inflammation, weak gum and teeth.

Probiotics & Prebiotics: Probiotics are potential therapy for maintaining oral health. It is used to reduce dental caries and periodontal diseases. Probiotics significantly maintains healthy balance of the bacteria flora in the mouth. Microbial growth promotes serious tooth decay and bad breath. Daily intake of probiotics in early childhood may result in less dental carries. Probiotics suppress the odor-producing bacteria, resulting in a decrease in the foul smelling gases arising in the mouth. It also helps to reduce the gum inflammation and plague formation caused by microbial growth. Prebiotics give the probiotics to exert their influence by aiding and boosting immunity.

Tip: AVOID FIZZY SUPPLEMENTS

Don’t buy the chewable Vitamin-C tablets or any kind of supplement that fizzes when you dissolve it in water. Chewable and fizzy vitamins lower the pH in your mouth and erode your tooth enamel big time. In fact, a recent study from the University of Helsinki found that fizzy supplements, including those containing calcium, caused teeth to lose minerals. The worst offenders were the fizzy vitamin-C supplements-they corroded the teeth so much that the layer below the enamel was exposed.

A healthy smile can help you look years younger. Just think about your diet, and weigh your need for six favorite supplements.