By taking statins, one or more patients will develop diabetes and 20% or more will experience disabling symptoms, including muscle weakness, fatigue, and memory loss

Cholecalciferol is preferred in patients with normal or mild renal impairment (GFR > 60 mL/min) with a normal intact PTH level.
In the presence of secondary hyperparathyroidism, which usually begins in stage 3 or 4 of CKD (GFR 30-59 mL/min and 15-29 mL/min, respectively), the preferred agent for supplementation is an activated vitamin D sterol (eg, calcitriol).

Taking antihypertensive medications at bedtime rather than in the morning has been shown to be associated with an increase in bedtime blood pressure (BP) decline toward a dipping pattern and better BP control and reduction in urinary protein excretion. Nocturnal hypertension is more common among patients with chronic kidney disease (CKD) who may thus experience greater effects of time medications for hypertension.

Ursodeoxycholic acid (UDCA) is used in the treatment of cholestatic liver diseases, gallstone dissolution, and for patients with hepatitis C virus infection to ameliorate elevated alanine aminotransferase levels. The efficacy of UDCA treatment has been debated and the mechanisms of action in humans have still not defined. Suggested mechanisms include the improvement of bile acid transport and/or detoxification, cytoprotection, and anti-apoptotic effects.

PPI use is linked to fracture risk

DHA reduces postpartum depression symptoms

Irreversible bone erosion occurs in RA, whereas subchondral bone sclerosis with synovial joint remodeling is typically characteristic of OA

The fixed-dose combination of aceclofenac and drotaverine is considered as a suitable, effective and well tolerated treatment option for primary dysmenorrhoea

Drugs can have harmful effects on mother and foetus at any time during the pregnancy. Use of medications during pregnancy requires a careful assessment of risks and benefits for them. During the first trimester teratogenic effects are frequent. There is higher risk from third to eleventh week of gestation. During the second and third trimester [...]

Twelve studies examined the impact of zinc supplements on the management of acute diarrhoea. Eleven of these showed a reduction in the duration of the diarrhoeal episode; in eight of these, the reduction was statistically significant. Five of the above studies also collected data on stool volume or frequency, and found that zinc supplements reduced [...]